Luciano Pomatto's research is focused on understanding economic interactions in situations of uncertainty. He studies methods for making decisions when the odds are unknown, both in terms of their quantitative properties as well as their conceptual implications. He also investigates how decisions are affected by different sources of risk. His published work has appeared in the American Economic Review, Econometrica, the Journal of Political Economy, the Annals of Statistics, Theoretical Economics, the Journal of Economic Theory, Sankhya, and Philosophy of Science.

Before arriving at Caltech in 2016, Pomatto was a Postdoctoral Associate at the Cowles Foundation at Yale University. He holds a PhD in managerial economics and strategy from the Kellogg School of Management at Northwestern University.