John P O'Doherty B.A. D.Phil



Associate Professor of Psychology

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Division of Humanities and Social Sciences
California Institute of Technology

 

 

 

 

RESEARCH INTERESTS

 

My main interest is to develop an understanding of the brain systems involved in representing stimulus reward value, predicting future reward, and in the flexible control of behavior to obtain reward. This is achieved through a combination of functional neuroimaging and human neuropsychological techniques.

Recently, I have been involved in the development of a new approach involving the application of computational models to functional neuroimaging data. This enables a much more powerful form of inference than is traditionally made in functional imaging studies, identifying regions with a response profile consistent with a specific computational process rather than merely reporting the 'activation' of a brain region in that task. Other interests include the functional neuroanatomy of human emotions, neural structures involved in social cognition, and the functional anatomy of the gustatory system.

For more details please go to the lab web-site:

BRIEF BIOGRAPHY

 

Since August 2007 I have been an Associate Professor of Psychology (without tenure) at the California Institute of Technology, Pasadena, CA. I obtained my BA in Mathematics and Psychology with first class honors at Trinity College Dublin, Ireland (1996), and completed a D.Phil in Experimental Psychology at the University of Oxford in the laboratory of Prof. Edmund Rolls (2001). From 2001-2004 I was a postdoctoral fellow at University College London at the Wellcome Dept of Imaging Neuroscience working with Prof. Ray Dolan. I was Assistant Professor of Psychology at Caltech from October 2004-August 2007.

 

COMPLETE LIST OF PUBLICATIONS  (as of Nov 2007)

 

2007

 

Schonberg, T, Daw, N, Joel, D and O'Doherty J.P. (2007). Reinforcement Learning Signals in the Human Striatum Distinguish Learners from Nonlearners during Reward-Based Decision Making. Journal of Neuroscience, 27(47):12860-7.

 

Kim H, Adolphs R, O'Doherty J.P., Shimojo S. (2007). Temporal isolation of neural processes underlying face preference decisions. PNAS, Nov 7, epub ahead of print.

 

O'Doherty J.P. (2007). The value in computation. Nature Neuroscience. 10(10):1225.

 

Bray S, Shimojo S, O'Doherty JP. (2007). Direct instrumental conditioning of neural activity using functional magnetic resonance imaging-derived reward feedback. Journal of Neuroscience, 27(28):7498-507.

 

Valentin VV, Dickinson A, O'Doherty J.P. (2007). Determining the neural substrates of goal-directed learning in the human brain. Journal of  Neuroscience 27(15):4019-26.

 

Plassmann H, O'Doherty J, Rangel A. (2007). Orbitofrontal cortex encodes willingness to pay in everyday economic transactions. Journal of Neuroscience 27(37):9984-8.

 

O'Doherty J.P. (2007) Lights, Camembert, Action! The role of human orbitofrontal cortex in encoding stimuli, rewards and choices. Ann N Y Acad Sci. 2007 Sep 13;epub.

 

Hampton AN, Adolphs R, Tyszka MJ, O'Doherty J.P. (2007). Contributions of the amygdala to reward expectancy and choice signals in human prefrontal cortex. Neuron 16;55(4):545-55.

 

Murray EA, O'Doherty JP, Schoenbaum G. (2007). What we know and do not know about the functions of the orbitofrontal cortex after 20 years of cross-species studies. Journal of Neuroscience, 27(31):8166-9.

 

O'Doherty J.P, Hampton A, Kim H.(2007). Model-based fMRI and its application to reward learning and decision making. Ann N Y Acad Sci. 2007 May;1104:35-53.

 

Balleine BW, Doya K, O'Doherty J, Sakagami M. Current trends in decision making. Ann N Y Acad Sci. 2007 May;1104:xi-xv.

 

Bray S, O'Doherty J. (2007). Neural coding of reward-prediction error signals during classical conditioning with attractive faces. J Neurophysiol. 97(4):3036-45

 

O'Doherty, J.  (2007) Human Neuroimaging of Reward Learning. In Squire, L. (Ed.): New Encylopedia of Neuroscience. London: Elsevier.

 

Hampton, AN and O'Doherty, J.P. (2007). Decoding the neural substrates of reward-related decision making with fMRI. PNAS, 104(4):1377-82.

 

Tobler P, O'Doherty J.P., Dolan RJ, Schultz W.(2007). Reward Value Coding Distinct From Risk Attitude-related uncertainty Coding in Human Reward Systems. J Neurophysiol. 97(2):1621-32;

 

2006

Hampton AN, Bossaerts P, O'Doherty J.P. (2006). The Role of the Ventromedial Prefrontal Cortex in Abstract State-Based Inference  during Decision Making in Humans. Journal of Neuroscience. 26(32):8360-7.

Kim, H., Shimojo S., and O'Doherty, J.P. (2006). Is avoiding an aversive outcome rewarding? The neural substrates of avoidance learning in the human brain. Plos Biology, 4(8):e233 (Epub)

Daw, N.*, O'Doherty, J.P *, Dayan P, Seymour B, Dolan RJ (2006). Cortical substrates for exploratory decisions in humans. Nature, 441:876-9.

Winston, J., O'Doherty, JP, Kilner JM, Perrett, PI, Dolan, RJ. (2006). Brain systems for assessing facial attractiveness. Neuropsychologia, Jul 5,(Epub).

Singer T, Seymour B, O'Doherty JP, Stephan KE, Dolan RJ, Frith CD. (2006). Empathic neural responses are modulated by the perceived fairness of others. Nature, 439:466-9.

O'Doherty JP, Buchanan TW, Seymour B, Dolan RJ (2006). Predictive neural coding of reward preference involves dissociable responses in human ventral midbrain and ventral striatum. Neuron, 49(1):157-66. 

Carter RM, O'Doherty JP, Seymour B, Koch C, Dolan RJ. Contingency awareness in human aversive conditioning involves the middle frontal gyrus. Neuroimage. 2006 Feb 1;29(3):1007-12.

Tobler, P., O'Doherty, J, Dolan, R.J. and Schultz, W. (2006)  Human neural learning depends on reward prediction errors. Journal of Neurophysiology, 95(1):301-10.

O'Doherty J.P and Dolan, R.J. (2006). The role of human orbitofrontal cortex in reward prediction and behavioural choice: insights from neuroimaging. In, Zald, D. and Rauch, S.L. (Eds.): The Orbitofrontal Cortex. Oxford: Oxford University Press.

2005

Seymour B, O'Doherty J, Koltzenburg M, Wiech K, Frackowiak R, Friston K, Dolan RJ. (2005) Opponent appetitive-aversive neural processes underlie predictive learning of pain relief. Nature Neuroscience,  8(9):1234-40. 

Coricelli G, Critchley HD, Joffily M, O'Doherty JP, Sirigu A, Dolan RJ. (2005).Regret and its avoidance: a neuroimaging study of

choice behavior.  Nature Neuroscience Sep;8(9):1255-62.

 

Kalisch R, Wiech K, Critchley HD, Seymour B, O'Doherty JP, Oakley DA, Allen P, Dolan RJ. (2005). Anxiety reduction through detachment: subjective, physiological, and neural effects. J Cognitive Neuroscience. 17(6):874-83.

 

Schultz J, Friston KJ, O'Doherty J, Wolpert DM, Frith CD. (2005).Activation in posterior superior temporal sulcus parallels parameter inducing the percept of animacy. Neuron. 2005 Feb 17;45(4):625-35.

 

Critchley HD, Rotshtein P, Nagai Y, O'Doherty J, Mathias CJ, Dolan RJ.(2005) Activity in the human brain predicting differential heart rate responses to emotional facial expressions. Neuroimage. 1;24(3):751-62.

 

2004

 

O'Doherty J. (2004) Reward representations and reward-related learning in the human brain: insights from human neuroimaging.Current Opinion in Neurobiology, 14(6):769-76.

 

Seymour B, O'Doherty J, Dayan P, Koltzenburg M, Jones AK, Dolan RJ, Friston KJ, Frackowiak RS. (2004) Temporal difference models describe higher-order learning in humans. Nature, 429:664-7.

 

O'Doherty J, Dayan P, Schultz J, Deichmann R, Friston K, Dolan RJ. (2004) Dissociable roles of ventral and dorsal striatum in instrumental conditioning. Science,  304:452-4. 

 

Singer, T., Seymour, B., O'Doherty, J., Kaube, H., Dolan, R.J., Frith, C.D. (2004) Empathy for pain involves the affective but not sensory components of pain. Science, 303 (5661): 1157-62.

 

Hornak, J., O'Doherty J., Bramham, J., Rolls, E.T., Morris, R.G., Bullock, P.R. and Polkey, C.E. (2004) Reward-related reversal learning after surgical excisions in orbitofrontal and dorsolateral prefrontal cortex in humans. Journal of Cognitive Neuroscience, Apr; (3):463-78.

 

Mechelli A, Crinion J.T, Noppeney U, O'Doherty J, Ashburner J, Frackowiak R.S., Price CJ. (2004)  Neurolinguistics: structural plasticity in the bilingual brain. Nature 431(7010):757.

 

O'Doherty J., Rolls, E.T., Kringelbach, M. (2004) Neuroimaging studies of crossmodal integration for emotion. In, Calvert G., Spence,

C. and Stein, B. Handbook of multisensory integration. MIT Press.

 

2003

 

O'Doherty J., Critchley H, Deichmann R, Dolan R.J. (2003) Dissociating valence of outcome from behavioral control in human orbital and ventral prefrontal cortices. J Neurosci. 2003 23(21):7931-9.

 

Rolls, E.T., O'Doherty, J., Kringelbach, M.L., Francis, S., McGlone, F. and Bowtell, R. (2003) Representations of pleasant and painful touch in the human orbitofrontal and cingulate cortices. Cerebral Cortex. Mar;13(3):308-17.

 

O'Doherty, J. (2003) Can't learn without you: predictive value coding in orbitofrontal cortex requires the basolateral  amygdala.Comment on Schoenbaum et al., Neuron, 39(5),731-3.

 

Kringelbach, M.L*, O'Doherty, J *, Rolls E.T., and Andrews C. (2003) The pleasantness of the flavour of food is represented in the human orbitofrontal cortex. Cerebral Cortex, 13(10):1064-71.

O'Doherty, J., Dayan, P. Friston, K.J., Critchley, H.D., Dolan, R.J. (2003) Temporal difference models and reward-related learning in the human brain. Neuron, 38(2), 329-337.

Gottfried, J., O'Doherty, J., Dolan, R.J. (2003) Encoding predictive reward value in human amygdala and orbitofrontal cortex. Science 301:1104-7.

 

 O'Doherty, J., Winston, J., Critchley, H.D., Perrett, D., Burt, D.M. and Dolan, R.J. (2003) Beauty in a smile: the role of medial orbitofrontal cortex in facial attractiveness. Neuropsychologia, 41(2):147-55.

 

Critchley HD, Mathias CJ, Josephs O, O'Doherty J, Zanini S, Dewar BK, Cipolotti L, Shallice T, Dolan RJ. Human cingulate cortex and autonomic control: converging neuroimaging and clinical evidence. Brain. 2003 2139-52.

 

Winston, J., O'Doherty, J. and Dolan, R.J. (2003) Common and distinct neural responses during direct and incidental processing of multiple facial emotions. Neuroimage, 20(1): 84-97.

 

Hornak J., Bramham, J., Rolls E.T., Morris R.G., O'Doherty J., Bullock, P.R., Polkey. C.E. (2003) Changes in emotion after circumscribed surgical lesions of the orbitofrontal and cingulate cortices. Brain, 26: 1691-712.

 

2002

 

O'Doherty J., Deichmann R., Critchley HD, Dolan R.J. (2002) Neural Responses during Anticipation of a Primary Taste Reward. Neuron 33:815-26.

 

Winston J.S., Strange B.A., O'Doherty J., Dolan R.J. (2002) Automatic and intentional brain responses during evaluation of trustworthiness of faces. Nature Neuroscience Mar;5(3):277-83.

 

Gottfried JA, O'Doherty J, Dolan RJ. (2002) Appetitive and aversive olfactory learning in humans studied using event-related functional magnetic resonance imaging. Journal of Neuroscience, Dec 15;22(24):10829-37.

2001

O'Doherty J, Kringelbach M.L., Rolls E.T., Hornak J., Andrews C. (2001) Abstract reward and punishment representations in the human orbitofrontal cortex. Nature Neuroscience Jan;4(1):95-102. 

 

O'Doherty J, Rolls ET, Francis S, Bowtell R, McGlone F. (2001) Representation of pleasant and aversive taste in the human brain. Journal of Neurophysiology Mar; 85(3):1315-21

 

2000

 

O'Doherty J, Rolls ET, Francis S, Bowtell R, McGlone F, Kobal G, Renner B, Ahne G. (2000) Sensory-specific satiety-related olfactory activation of the human orbitofrontal cortex. Neuroreport Mar 20;11(4):893-7.

Mellanby J, Martin M, O'Doherty J. (2000). The 'gender gap' in final examination results at Oxford University. British J Psychol. 2000 91 (Pt 3):377 90.

*Authors contributed equally


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